DNA Consultants Home of the DNA Fingerprint

Authentic sequences from the ancient human past are a rarity in the world of DNA testing. But when a team of archeologists put the mummies of King Tut and his immediate family on the operating table in 2010, they were successful in deriving almost complete DNA profiles for the boy king and others in the Amarna dynasty that ruled Egypt more than three thousand years ago. Now three of the DNA signatures of Egyptian pharoahs from that famous forensic study by Zahi Hawass and the Supreme Council of Antiquities in Cairo--plus others newly discovered--are available as part of a commercial direct-to-the-consumer autosomal DNA testing panel.

In October 2012, DNA Consultants launched its Rare Genes from History Report. Based on a customer's DNA fingerprint or autosomal profile, the additional analysis sells for $289. It compares your laboratory results with 26 rare alleles or ancestry markers whose trail has been traced through world history and evolving population changes by the company's statisticians. 

Take the Thuya Gene, for instance. Like most of the other Rare Genes from History, it has an African origin in deep time. But it experienced its greatest expansion in ancient Egypt, where it was carried by the queens of Upper and Lower Egypt and High Priestesses of the temples. It was reported in the profile of Queen Thuya's mummy, and we can see that she passed it to her children, grandchildren and descendants. King Tut was a great-grandson and has it, according to the new forensic evidence.

Today, as many as one-fourth of all people on earth would test positive for the Thuya Gene. It is twice as common in Somalia as outside Africa and is found in 40% of Muslim Egyptians.

That's not so rare after all, but unsurprising. Egyptian civilization lasted for three thousand years and sowed the seed of its peoples and ideas throughout the world. We can imagine that Autosomal Thuya started out in East Africa about 100,000 years ago, and that her descendants were prominent in the first out-of-Africa group as well as in the Middle Easterners who helped spread agriculture, animal husbandry, religion and settled town life to Europe. 

The spirit of Thuya lives on in 27% of Jews who have been tested in academic studies. Extrapolating to world population figures, that's nearly 400,000 people, about evenly divided between the United States and Israel.

See also "Prelaunch of New Autosomal Products" (August 26, 2012)
"Rare Genes from History" (webpage)
"Rare Genes from History Panel Now Available for $289.00"

The classic DNA study by the Supreme Council of Antiquities in Cairo, Egypt is: Hawass Z, Gad YZ, Ismail S, et al. Ancestry and Pathology in King Tutankhamun's Family. JAMA. 2010;303(7):638-647. The feat by scientists has also been featured on Discovery Channel. 

The Cherokee called them the Moon People. The Utes and Paiutes spoke of a hideous race of cannibals ten feet tall living in caves. And the Choctaw also have an account of the race of giants that first colonized the Ohio Valley. 

From Old World Roots of the Cherokee, chapter 5, "America's Middle Ages," pp. 78-79, we read:

What kind of Indians lived in the territory the Choctaw and Chickasaw carved out for their new home? According to their traditions, reports Cushman, as confirmed by excavations of bones in Tennessee, it was a “race of white giants”:

[T]he tradition of the Choctaws . . . told of a race of giants that once inhabited the now State of Tennessee, and with whom their ancestors fought when they arrived in Mississippi in their migration from the west, doubtless Old Mexico. Their tradition states the Nahullo (race of giants [literally, wizards]) was of wonderful stature; but, as their tradition of the mastodon [which used to be found on the Great Plains], so this was also considered to be but a foolish fable, the creature of a wild imagination, when lo! Their exhumed bones again prove the truth of the Choctaws’ tradition (151).

These giants could have been Rafinesque’s Atlans.

Cushman then recounts the discovery in 1880 at a burial mound site near Plano, Texas, of human bones “of enormous size . . . the femoral bones being five inches longer than the ordinary length, and the jaw bones . . . so large as to slip over the face of a man with ease.” Cushman goes on to identify them with the older occupants of North America called Allegewi or Taligewi (Talegans). Many historians, moreover, speculate they were the builders of the Adena mounds.

As for the Chickasaw, Cushman notes that they have no record of their history before the colonial period, although it is assuredly "the same as the Choctaws, being one tribe and people until the division made by their two chiefs Chikasah and Chahtah many years after their arrival and location east of the Mississippi River" (p 358). Of the Natchez, Cushman records that they, "if tradition may be believed, also came from Mexico where they had lived for centuries" (p 440).

A story was told by the Comanches in 1857: 

Innumerable moons ago, a race of white men, ten feet high, and far more rich and powerful than any white people now living, here inhabited a large range of country, extending from the rising to the setting sun. Their fortifications crowned the summits of the mountains, protecting their populous cities situated in the intervening valleys. They excelled every other nation which was flourished, either before or since, in all manner of cunning handicraft—were brave and warlike—ruling over the land they had wrested from its ancient possessors with a high and haughty hand. Compared with them the palefaces of the present day were pygmies, in both art and arms. They drove the Indians from their homes, putting them to the sword, and occupying the valleys in which their fathers had dwelt before them since the world began. At length, in the height of their power and glory, when they remembered justice and mercy no more and became proud and lifted up, the Great Spirit descended from above, sweeping them with fire and deluge from the face of the earth. The mounds we [i.e. the speaker Chief Rolling Thunder and his Spanish listener] had seen on the tablelands were the remnants of their fortresses, and the crumbling ruins that surrounded us all that remained of a mighty city.[i]

The word Nahoolo or Nahullo “is now emphatically applied to the white race and no other . . . The Nahullo were of white complexion, according to Choctaw tradition, and were still an existing people at the time of the advent of the Choctaws to Mississippi,” concludes Cushman (p 153) . In agreement, the Indian trader Adair often refers to the Nani Ishtahoolo as departed white ghosts vested with spiritual powers whose descendants were priests and magicians. Their cries and magic spells could still be heard in the mounds like those at Ocmulgee.[ii] These references contribute to the suspicion that the “Indians” who preceded Asiatic tribes from Mexico were, as we would say today, Caucasian.

About exactly a year ago on this blog, we published a post about "Neanderthals in America," mentioning also the peculiar archaic skeleton that is now a roadside attraction in Arizona, called The Thing. In the meantime, we acquired a copy of Fritz Zimmerman's book, The Nephilim Chronicles, which reproduces over 300 historical accounts of Giant skeletons. Many are associated with the earliest mound sites in America, but Zimmerman's survey of this worldwide phenomenon ranges from the Hunter-Fisher People of northeast Europe and Red Paint People whose movements were circumpolar to the giants of the Bible, noted by the Babylonian Talmud as having double rows of teeth, and "Giants' Remains in the British Isles" (pp. 157-65).

Navajo legends speak of the Starnake People, a regal race of white giants endowed with mining technology who dominated the West, enslaved lesser tribes and had strongholds all through the Americas. They were either extinguished or "went back to the heavens." The name may be a corruption of the Biblical race known as Anakim (Num. 13:33, Deut. 1:28). The name Og (Hebrew "chief") appears to be characteristic (see Zimmerman, pp. 188-91). The ogham alphabet is attributed to this cultural founder. 

Certainly, many of the mound sites uncovered in the nineteenth century tell a story of constant warfare by incoming Asiatic tribes  against the giants occupying the land. One grisly scene showed thousands of skeletons, male, female and young heaped in a mass grave, with warriors' skulls pierced by arrows. It would appear that as these aboriginal inhabitants of the Ohio Valley were gradually displaced, some members of their society went over into the ranks of the new conquerors, bequeathing a strain of great stature still noticeable, for instance, in the Mobilian chief Tuscaloosa and DeSoto's Indian queen Cofitachiqui, both of whom were said to be seven feet tall.

We are struck by the following traits of this giant race or ethnic group from human prehistory:

• Mother Goddess religion
• Copper (not bronze) axes 
• Polished slate tools including fishing plummets, which were apparently regarded as sacred
• Belief that the Grandmother Moon was the repository of souls
• Diet emphasizing shellfish (for which the double row of teeth probably was selected as an evolutionary advantage in their beachcomber origin out of Africa?)
• Building of fish weirs in North American rivers to trap migrating eels
• Certain vegetarian habits (wild rice, for instance)
• Inscriptions on artifacts, especially pipes, often buried with the dead
• Use of coal and petroleum
• Weaving and looms
• Knowledge of seafaring, mathematics and engineering, including canals and irrigation
• Burying of a dog with a child to guard the latter in the afterlife
• A language apparently Afro-Asiatic and close to Semitic tongues
• Kingcraft:  nobles were buried in seated positions on thrones surrounded by a coterie of their retainers

If you ask this question of the archeological establishment today, the answer you are likely to receive is something like "Darned, if we know!" 

Whoever they were, they appeared and disappeared suddenly with about 1500 years in between. Phoenix where the Salt and Gila rivers meet was their center, and the site of the present-day Pueblo Grande Museum and Archeological Park near Sky Harbor is believed to have been their capital city, with an area population at its height of 50,000 people--the greatest civilization of North America, excluding Mexico.

Their name means "the vanished ones" in the modern Pima Indian or O'odham language. The Salt River Pima-Maricopa Indian Community located in the metropolitan Phoenix area now occupy the Hohokam homeland, although they and the related Papago (Tohono or Desert O'odham) are ambivalent about whether they are the descendants or conquerors of the Hohokam.

Harold Sterling Goodwin, who first discovered the Hohokam in his excavations of Snaketown in the 1920s, thought they were a Central American culture like the Maya or Zapotec. It is true that when they showed up about a century before the Common Era, they brought pottery, corn and beans agriculture and sophisticated canal irrigation, and that none of these arts indicate any preliminary or introductory stages of development in the Arizona archeological record. It would be 800 more years before the truly indigenous Indians (called Basketweavers) acquired pottery and the other appurtenances of civilization, including the village architecture we call Puebloan.

A giant in Southwestern archeology, Goodwin fell from grace in the 1940s when he had the audacity to disagree about the emerging picture of Basketweaver-Pueblo-Spanish cultural phases and persist in a diffusionist theory of prehistory emphasizing Austronesian migrations rather than Asiatic influences. He went on to write a synthesis of American Indian studies titled A History of the Ancient Southwest (1957), a straightforward survey of the ancient civilizations that were overrun by the Uto-Aztecan, Navajo and Apache intruders beginning about 1100.

Another bad boy of academia, Barry Fell, believed the Hohokam came from the Middle East and North Africa, where they had perfected adobe construction and canal irrigation of crops. Fell pointed to the parallels between Pima and Papago and Berber languages. 

The Salt and Gila Rivers ran year round when the Hohokam built their system of government and katchina-based religion. Some of the canals were 50 feet wide and 16 miles long. There were four or more networks of irrigation canals totaling more than a thousand miles long. Since they built grass huts and caliche-plastered mud mounds and villages, though, the footprint of the Hohokam today is mostly melted away by erosion, and their earliest habitation spots are forever lost in the changing shoreline. They used few timbers, so tree-ring chronologies cannot be applied to them.

Thus the Hohokam are likely to remain permanent mysteries to us. But a little hint:  if you read their name as Semitic, it means "Sea Peoples." Snaketown can be understood as "boat-town" as well as the modern local Indians' calque "place where there are lots of rattlesnakes."

Their genetic signature, at any event, seems to be haplogroup B, like the Maya, other Pueblo Indians and Southeast Asians.








  

 

Environmental doctor Anne Marie Fine of Scottsdale, Ariz. was one of the first physicians to adopt genetic tests as part of her practice in 2002. Recently, she gave a brief introduction to the role epigenetics plays in human diversity at the 12th annual Conference on Diversity in Vancouver, British Columbia. Her paper with Donald N. Yates, "Epigenetics and the Autosomal DNA of Human Populations: Clinical Perspectives and Personal Genome Tests," should appear soon, but in the meantime you can watch a short video of her epigenetics presentation (5:37). Epigenetics is beginning to loom as a much more important factor in multigenerational health than mere genetics. We would be interested in your comments!

Geneticists seized the opportunity provided by an international Basque cultural event held in Idaho in 2010 to sample volunteers and study Basque DNA. The result was two studies, including "The Y-STR Genetic Diversity of an Idaho Basque population, published in Human Biology.

It was the first DNA study to document the spread of the Basque male chromosome overseas. The Basque people were renowned seafarers.

"The idea is to better understand health risks for Basque people, including an increased incidence of both Alzheimer's and Parkinson's diseases," said Josu Zubizarreta, a Boise State graduate who conducted research with the lead author, Greg Hampikian.

Mitochondrial DNA, which reflects a deeper history, was also studied.

Basques are credited with the invention of the rudder. They provided the crew and navigators for Magellan. Basque names are common on antique maps. The Bay of Biscayne is named for them, and many harbors, points and landfalls on the Atlantic Coast of North America are thought to come from the Basque language, which is known as an isolate and is unrelated to other European languages.

Sculpture of Basque sailor, Victorio Macho, Toledo. Travelpod.

Citation
Zubizarreta, Josu; Davis, Michael C.; and Hampikian, Greg (2011) "The Y-STR genetic diversity of an Idaho Basque population, with comparison to European Basques and US Caucasians," Human Biology: Vol. 83: Iss. 6, Article 2.
Available at: http://digitalcommons.wayne.edu/humbiol/vol83/iss6/2

Gene surfing is a process in population expansion whereby certain variations become prominent and dominant in a short time, appearing to skip the slow, steady, uniform accumulation of variegation and diversification. According to a study of the population structure and genealogies of Saguenay Lac-Saint-Jean in Quebec, this type of drastic change accompanied the immigrant wave front that spread over the area in the 17th century. "Deep Human Genealogies Reveal a Selective Advantage to Be on an Expanding Wave Front" in Science magazine describes the resulting demographics.

Abstract
Since their origin, human populations have colonized the whole planet, but the demographic processes governing range expansions are mostly unknown. We analyzed the genealogy of more than one million individuals resulting from a range expansion in Quebec between 1686 and 1960 and reconstructed the spatial dynamics of the expansion. We find that a majority of the present Saguenay Lac-Saint-Jean population can be traced back to ancestors having lived directly on or close to the wave front. Ancestors located on the front contributed significantly more to the current gene pool than those from the range core, likely due to a 20% larger effective fertility of women on the wave front. This fitness component is heritable on the wave front and not in the core, implying that this life-history trait evolves during range expansions.

So gene surfing in an expanding colonization phase can produce a genetic revolution whose effects will be felt for hundreds or thousands of years downstream in history.

We wonder if the same wave front demographics might explain some of the following population phenomena:

• Large scale triumph of Norman male lineages following the conquest of England in 1066.
• Selective expansion of Middle Eastern genes in Tennessee (including Cherokee families, Jewish male and female lines and Melungeons)
• Relatedness among Jews and "Jewish diseases"
• Diversity-within-uniformity of Polynesians
• Population replacement of Old European (U, N) by Middle Eastern genes (T, J)  in Europe as a result of the Neolithic Agricultural Revolution

Many students of history are puzzled why old populations have the allele frequencies and heterozygosity clines they have. Genetic drift is only part of the answer. Gene surfing and selection in deep history are the rest of it.

More information about Melungeons
Toward a Genetic Profile of Melungeons in Southern Appalachia
Melungeon Studies
Melungeon Match

According to a professor of immunology and microbiology at Stanford University, humans were able to survive, spread and expand their populations once they left Africa because of immunities to disease they acquired from Neanderthals and Denisovans, who had lived in Europe and Asia already for hundreds of thousands of years.

A review of the new research appears in the online science magazine Discover under the date of June 20, 2011. The professor's name is Peter Parham.

Crux of the matter, according to Royal Society report

• Parham began by taking a close look at a family of genes called  human leukocyte antigens (HLAs), which play a central role in our body’s immune responses. We are able to react to a wide array of diseases because our HLA genes are highly variable, each containing dozens of  alleles (forms of genes).
• Our ancestors in Africa, however, would have had a small number of HLA alleles because they likely traveled in small bands and had little contact with other groups. Moreover, their HLAs would have only protected them against African diseases.
• When Parham compared the HLAs of modern humans with those of Neanderthals and Denisovans, he noticed some overlaps. In particular, he found that HLA-C*0702, an allele common in Europeans and Asians but nonexistent in Africans, was also present in the Neanderthal genome. Similarly, HLA-A*11, which is found in modern Asians but not in Africans, popped up in Denisovan DNA.
• Overall, about 50 percent of HLA Class I alleles in Europeans seemed to come from Neanderthals, 70 to 80 percent in East Asians from Denisovans, and 90 to 95 percent in Papuans from Denisovans, Parham said at a recent Royal Society meeting.

DNA Consultants introduced its Neanderthal Index, a measure of affinity with archaic populations of Europe and the Middle East, one year ago this month.

Dr. Donald Yates says he is planning a visit to Vindija cave near Varazdin in Croatia this month to see firsthand the world's most important site for the discovery of Neanderthal bones and lifeways, dating to about 30,000 years ago.

Human history changed drastically with the 1974 Neanderthal discoveries at Vindija Cave. Photo Tomislav Kranjcic.

Did Neandertals Linger in Russia's Far North?

For more than 150,000 years, Neandertals had Europe's lush river valleys to themselves. Then, beginning about 40,000 years ago, modern humans swept in from Africa and the Near East, spreading rapidly from east to west. Soon, the archaeological evidence suggests, the Neandertals retreated to “refugia” in southern Europe, such as Spain and Portugal—their last holdouts before going extinct.

Or were they? On page 841, a research team claims that some of the last Neandertals may have taken refuge in the dark Arctic north rather than the sunny south. At the 32,000-year-old site of Byzovaya in Russia's Polar Ural Mountains, which at 65 degrees latitude is as far north as Iceland, archaeologists found stone tools they argue are typical of those long associated with Neandertals in Europe...

Read abstract.

Note: This may explain why Finno-Uralic is one of the strong contributors to a high score on our Neanderthal Index.

Byzovaya Cave in Russia's Polar Ural Mountains with Neanderthal artifacts.

Analysis of ancient nuclear DNA, recovered from 40,000-year-old remains in the Denisova Cave, Siberia, hints at the multifaceted interaction of human populations following their migration out of Africa.

The new discipline of palaeogenetics is delivering increasing dividends, the latest news coming from Reich, Pääbo and colleagues on page 1053 of this issue. The authors' analysis of nuclear DNA of a human-like finger bone, found in Denisova Cave in southern Siberia, points towards a complex model of migration and colonization after anatomically modern humans moved out of Africa some 50,000–60,000 years ago.

Ever since 1925, when Raymond Dart's report of the first Australopithecus skull in southern Africa upended Victorian views of human origins, there has been debate over whether our species arose only once and spread throughout the world, replacing all extant species of Homo, or whether our ancestors interbred with the other populations and subspecies. The most extreme version of the 'candelabra' model of human origins — according to which human species arose multiple times independently of our Homo ergaster ancestors — has been largely discounted.

But it has been difficult to assess more nuanced models, such as the possibility of genetic exchange with some archaic populations, including Neanderthals, and now perhaps ancient Siberians. Until recently, genetic data and interpretation of the fossil record seemed to favour a complete-replacement model, in which all human species trace all of their genetic ancestry to a single origin in one or more African populations of moderate size some 200,000 years ago2, 3, 4, 5. However, the Denisovan nuclear genome sequence, along with that of Homo neanderthalensis published by some of the same authors6, suggest that the out-of-Africa population history of Homo sapiens is probably much more intertwined than previously thought, with more intertwining in some parts of the world than others.

Read more and follow discussion at Nature.

Triangles and circles respectively represent sampling locations of Neanderthal remains and of present-day human genomes. The blue arrows indicate generally accepted major migrations of anatomically modern humans, following their departure from Africa 50,000–60,000 years ago. At this time, there were two primary archaic species in Eurasia, Neanderthals and Homo erectus; Reich, Pääbo and co-workerssuggest that a third group was also present, represented by the ancient Denisovan genome. From ancient DNA, they identify additional putative events involving two episodes of limited gene flow: first, genetic admixture from Neanderthals to modern humans, shortly after the exit from Africa; second, subsequent admixture with the archaic population exemplified by the nuclear DNA extracted from the Denisova finger bone. This second event seems to affect only the ancestors of present-day Melanesians, who are thought to have colonized Papua New Guinea some 45,000 years ago. African populations, both past and present, are genetically highly diverse, as indicated by the multiple labels.

See also "New Hominin Probably Explains Distinctiveness of Melanesians"

You hear a lot of talk about the Neolithic Revolution--the gradual adoption and spread of agriculture, animal husbandry and town life by our prehistoric European ancestors--but the most important epoch in the course of civilization goes largely unnoticed in the history books. That was the abrupt shift from matriarchy and worship of the Great Goddess to the warrior-based governments and language stocks of the steppe-dwelling Indo-Aryan barbarians who invaded Old Europe beginning in the late fourth millennium BCE.

The roots of Europe's original female-oriented religion are lost in the mists of the early Stone Age, and may even precede the arrival of "modern humans" in Europe and be part of the heritage of Neanderthals. This substratum of a long-lasting peaceful hunter-gatherer society organized around the religion of the Great Goddess absorbed the spreading practice of agriculture from the Middle East beginning in the fifth millennium and reached its apogee of development in a pure form in the fourth millennium.

The cult of the Great Goddess, depicted here in an enthroned version with flanking felines from Çatal Hüyük, an 8,000-year-old shrine in present-day Turkey (p. 107), was the lifelong object of study by Lithuanian-American archeologist Marija Gimbutas, whose most influential book is The Language of the Goddess (London:  Thames & Hudson, 2006). 

The axe fell on this ancient civilization--quite literally--around 3000 BCE. As confirmed in Jane McIntosh's Handbook to Life in Prehistoric Europe (New York:  Facts on File, 2006), there was a clear line of demarcation between old and new Europe, from the Balkans to Britain, Spain and Scandinavia. The archeological record tells the story of a sweeping and abrupt end to things. The first metal weapons appear in the graves of elite males along with hoards of gold and jewels. Axes previously used to clear forests for agriculture are now battle-axes. Burials are single rather than family and clan-oriented. Whole villages were massacred and depopulated. Fortifications grew as violence escalated. The horse, venerated as just one of the totem animals of the Goddess since the early Stone Age, becomes the symbol of the warrior, along with the chariot and boat. Rock art features ithyphallic warriors wielding weapons or shooting arrows at each other. The transition can also be seen in the establishment of the Pharaohs in Egypt about 3500 BCE.

The invaders brought their male pantheon of war gods, Indo-European languages, aristocratic forms of government and Central Asian/Caucasian genes. The goddess cult underwent radical male adaptations, surviving in out-of-the-way places like Crete and Brittany. 

So, rather than one transformation, European civilization first went through a Neolithic Revolution, then conversion to warrior-dominated patriarchal societies. It can be postulated that the matriarchal societies eagerly adopted agriculture but exhausted soils, destroyed vital forests and became weaker and smaller-bodied due to a changed diet, falling prey around 3000 BCE to the barbarian warriors of the steppe, who found the accumulation of wealth and unprotected agrarian settlements of Old Europe easy pickings. Climate change could have been a contributing factor.

James Joyce called history "the nightmare from which one cannot wake." If we take a long view of human events, this nightmare began about five thousand years ago. Other-worldly religions like Christianity introduced a further element of alienation and turning away from the sources of life. Before that, people were happily alive, awake, in tune with nature and celebrated life under the auspices of matriarchy.

Assailants with bows and arrows attack

a fortified Neolithic settlement in Furfooze,

France, who defend themselves by hurling

stones and raising clubs. Reconstruction

from Louis Figuier, Primitive Man (London: 

Chatto and Windus, 1876).