If you want to discover your genetic history and where you came from... you’ve found the right place!

888-806-2588

review of scientific and news articles on dna testing and popular genetics

Why Italians Live So Long

Friday, August 05, 2011

We just returned from a long trip through Italy and were struck by Italians' apparent immunity to all the forces of aging that besiege Americans and other members of the First World. "Italian men," said Paolo, our driver, "smoke, drink, womanize and curse all day and live to a hundred." Maybe the answers why are in this new report on Italian longevity.

The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians

Alberto Montesanto1, Valeria Latorre1, Marco Giordano1, Cinzia Martino1, Filippo Domma2 and Giuseppe Passarino1

  1. 1Department of Cell Biology, University of Calabria, Rende, Italy
  2. 2Department of Economics and Statistics, University of Calabria, Rende, Italy

Correspondence: Professor G Passarino, Department of Cell Biology, University of Calabria, 87036, Rende, Italy. Tel: +39 0984 492932; Fax: +39 0984 492911; E-mail: g.passarino@unical.it

European Journal of Human Genetics (2011) 19, 882–886; doi:10.1038/ejhg.2011.40; published online 16 March 2011

Abstract

Many epidemiological studies have shown that parents, siblings and offspring of long-lived subjects have a significant survival advantage when compared with the general population. However, how much of this reported advantage is due to common genetic factors or to a shared environment remains to be resolved.

We reconstructed 202 families of nonagenarians from a population of southern Italy. To estimate the familiarity of human longevity, we compared survival data of parents and siblings of long-lived subjects to that of appropriate Italian birth cohorts. Then, to estimate the genetic component of longevity while minimizing the variability due to environment factors, we compared the survival functions of nonagenarians' siblings with those of their spouses (intrafamily control group).

We found that both parents and siblings of the probands had a significant survival advantage over their Italian birth cohort counterparts. On the other hand, although a substantial survival advantage was observed in male siblings of probands with respect to the male intrafamily control group, female siblings did not show a similar advantage. In addition, we observed that the presence of a male nonagenarians in a family significantly decreased the instant mortality rate throughout lifetime for all the siblings; in the case of a female nonagenarians such an advantage persisted only for her male siblings.

The methodological approach used here allowed us to distinguish the effects of environmental and genetic factors on human longevity. Our results suggest that genetic factors in males have a higher impact than in females on attaining longevity.

Comments

seema commented on 09-Aug-2011 07:41 AM

nice....!

Wendy Cunningham commented on 17-Nov-2011 10:01 PM

I think that is very interesting. I am 1/8 Italian from my mom's side of the family. My mom's mother was 1/2 Italian. Her name was Mildred Florence Muccia. She was born on Nov 12 1913 in Brooklyn, New York. Her father was Italian. His name was Peter Muccia.
The mother was Miriam Bansley. Both were from New York. I do not know much about them. But I would love to find their living relatives if only I knew where they are at! I am 48 but people mistake me for 29 years old. It's true that I look very young for my
age. I happen to be very healthy. I was told by a palmist that I will live a long time. I guess the researchers are right about our Italian dna carrying the genes of longivity. I hope my Mom will live for a long time. She is 71 now.

Paul commented on 28-Apr-2012 08:00 PM

Well it seems my Italian side got the short end of that stick. The oldest was my grandmother at 91 - but she was several years with Alzheimer's. My uncle just died at 84. Other than that, no others made it to the 80s. My dad was 66.


Please tell us what you think

Name, website, and email are optional; if we publish your comment, your name will be shown, and may be linked to your website if provided, but the email you enter will not be published.





Captcha Image


Recent Posts


Tags

Normans Population genetics Anne Marie Fine Joseph Andrew Park Wilson Odessa Shields Cox Elvis Presley DNA Havasupai Indians Basques Daniel Defoe Zuni Indians archeology mutation rate human migrations Bureau of Indian Affairs Henriette Mertz Y chromosomal haplogroups rapid DNA testing Majorca surnames crypto-Jews Israel cancer Sonora Science magazine Nephilim, Fritz Zimmerman Louis XVI Washington D.C. John Butler Johnny Depp ISOGG Virginia genealogy Society for Crypto-Judaic Studies breast cancer Cooper surname Rafael Falk Melba Ketchum Valparaiso University Cherokee Freedmen Cajuns haplogroup B Black Irish Colima Echota Cherokee Tribe of Alabama Stephen Oppenheimer mental foramen Charles Perou Harry Ostrer Russell Belk Bryony Jones Roma People Elizabeth DeLand Mexico Choctaw Indians Grim Sleeper Jewish genetics Irish history Jewish GenWeb Mucogee Creeks Gypsies Black Dutch American Journal of Human Genetics GlobalFiler Ananya Mandal Oxford Journal of Evolution Wendell Paulson Nature Genetics andrew solomon private allele Sinti Gregory Mendel Britain Sasquatch Clovis Melungeon Movement Marija Gimbutas Douglas Owsley DNA Forums FBI Early Jews and Muslims of England and Wales (book) haplogroup N National Geographic Daily News Gila River PNAS Monica Sanowar anthropology Bode Technology Arizona Ukraine John Wilwol Eric Wayner Tintagel Cree Indians familial Mediterranean fever Cherokee DNA Project Mark Stoneking First Peoples 23andme Asian DNA BATWING bar mitzvah cannibalism Ostenaco pheromones Irish Central haplogroup U Sorbs metis DNA testing companies Cohen Modal Haplotype prehistory Paleolithic Age Kitty Prince of the Bear River Athabaskans hominids Bill Tiffee North Carolina Chris Tyler-Smith Tom Martin Scroft Kari Carpenter Isabel Allende Middle Eastern DNA Pima Indians DNA security Wendy Roth Rebecca L. Cann Holocaust Robinson Crusoe ged.com Bentley surname research William Byrd Salt River Gunnar Thompson occipital bun Ancestry.com Cismar Lab Corp aliyah family history Constantine Rafinesque bloviators Peter Parham haplogroup R King Arthur Wikipedia National Museum of Natural History Donald N. Yates Jone Entine Ron Janke The Nation magazine B'nai Abraham history of science Smithsonian Magazine Sea Peoples Phoenix Virginia DeMarce Discover magazine New Mexico Hawaii Kate Wong Old Souls in a New World population genetics Bigfoot Slovakia Ripan Malhi Hertfordshire Patrick Pynes Jewish contribution to world literature Neanderthals haplogroup W Irish DNA Cismaru Satoshi Horai DNA Diagnostics Center Teresa Panther-Yates Dragging Canoe Victor Hugo Colin Renfrew Arizona State University DNA Fingerprint Test Sinaloa clan symbols Stacy Schiff Greeks Epigraphic Society French DNA Panther's Lodge Life Technologies India far from the tree Altai Turks Lithuania Melungeons Richmond California Ireland Science Daily, Genome Biol. Evol., Eran Elhaik, Khazarian Hypothesis, Rhineland Hypothesis Kennewick Man evolution admixture Denisovans Walter Plecker race Svante Paabo European DNA Beringia EURO DNA Fingerprint Test Jalisco Douglas Preston Ethel Cox Micmac Indians Jim Bentley Austronesian, Filipinos, Australoid ethics haplogroup L epigenetics Juanita Sims rock art Secret History of the Cherokee Indians genetics methylation George van der Merwede Hohokam Indians Carl Zimmer Family Tree DNA Bulgaria ethnicity Cave art haplogroup J Maya haplogroup E Neolithic Revolution microsatellites Algonquian Indians Stan Steiner Anne C. Stone mummies prehistoric art Nayarit Jews and Muslims in British Colonial America Horatio Cushman New York Review of Books Cleopatra Ashkenazi Jews human leukocyte antigens Peter Martyr Plato ethnic markers M. J. Harper Cherokee DNA Abraham Lincoln Karenn Worstell Anacostia Indians Cancer Genome Atlas medicine Phoenicians King Arthur, Tintagel, The Earliest Jews and Muslims of England and Wales Alabama Oxford Nanopore Gravettian culture Barack Obama Jack Goins Middle Ages DNA databases Fritz Zimmerman National Health Laboratories Chauvet cave paintings research Holocaust Database Riane Eisler Eske Willerslev genetic determinism Telltown El Castillo cave paintings religion NPR FDA Old World Roots of the Cherokee Janet Lewis Crain Applied Epistemology oncology Kentucky Henry VII Pomponia Graecina Italy University of Leicester Waynesboro Pennsylvania England China clinical chemistry French Canadians Richard III Sam Kean statistics HapMap Panther's Lodge Publishers X chromosome Rutgers University Shlomo Sand Smithsonian Institution Mary Kugler Finnish people Michoacan Jesse Montes Ziesmer, Zizmor Elizabeth C. Hirschman Genome Sciences Building Sarmatians Tifaneg Thuya Penny Ferguson DNA Fingerprint Test Nature Communications haplogroup H palatal tori Romania BBCNews Israel, Shlomo Sand haplogroup C Austro-Hungary Asiatic Echoes Germany Harold Sterling Gladwin Richard Lewontin Rich Crankshaw Douglas C. Wallace James Shoemaker Europe Khazars Leicester news Colin Pitchfork Chris Stringer phenotype Iran Charlotte Harris Reese Muslims in American history myths Asiatic Fathers of America Etruscans Cornwall Sir Joshua Reynolds corn education AP Chromosomal Labs Bode Technology Timothy Bestor Scientific American haplogroup Z Erika Chek Hayden Marie Cheng Scotland Joel E. Harris New York Academy of Sciences population isolates Acadians James Stritzel Phillipe Charlier Promega Taino Indians Patrick Henry Hopi Indians Pueblo Grande Museum Rare Genes genomics labs George Starr-Bresette haplogroup T Barnard College ancient DNA Michael Schwartz Y chromosome DNA university of North Carolina at Chapel Hill alleles Alec Jeffreys Tennessee Celts Olmec Richard Dewhurst London North African DNA N. Brent Kennedy Sizemore Indians mitochondrial DNA Cherokee Nation of Oklahoma linguistics Mark Thomas Brian Wilkes Russia Chuetas seafaring genealogy Sizemore surname Elzina Grimwood Native American DNA Pueblo Indians Charles Darwin Solutreans Caucasian climate change Richard Buckley autosomal DNA Indian Territory Indo-Europeans Arabia Freemont Indians Phyllis Starnes Miguel Gonzalez Les Miserables single nucleotide polymorphism personal genomics haplogroup X MHC art history Discovery Channel Anglo-Saxons Bering Land Bridge polydactylism Nova Scotia American history Anasazi megapopulations Kurgan Culture Mohawk peopling of the Americas DNA magazine Daily News and Analysis Helladic art Ancient Giantns Who Ruled America Maronites Ari Plost Puerto Rico Akhenaten Khoisan Rush Limbaugh Roberta Estes Michael Grant Patagonia Hispanic ancestry Yates surname haplogroup M health and medicine Stony Creek Baptist Church Melanesians INORA Albert Einstein College of Medicine Egyptians Theodore Steinberg Tutankamun Early Jews of England and Wales powwows Joseph Jacobs giants Jewish novelists Keros Jon Entine IntegenX consanguinity pipe carving Thruston Tablet Zizmer CODIS markers Moundbuilders Bryan Sykes FOX News Native American DNA Test Navajo human leukocyte testing ENFSI Central Band of Cherokees Melungeon Union Tucson Jews When Scotland Was Jewish Antonio Torroni Luca Pagani Genex Diagnostics Wellcome Trust Sanger Institute District of Columbia Stone Age haplogroup D Abenaki Indians Columbia University African DNA Kari Schroeder immunology John Ruskamp Nikola Tesla Comanche Indians Henry IV genetic memory Central Band of Cherokee Zionism Terry Gross Philippa Langley forensics Current Anthropology Nancy Gentry hoaxes Wales Lebanon David Cornish Mary Settegast Bradshaw Foundation Melungeon Heritage Association Hohokam Turkic DNA Mildred Gentry New York Times Native American Graves Protection and Repatriation Act Monya Baker Dienekes Anthropology Blog Mother Qualla Harold Goodwin Amy Harmon Arabic Belgium Great Goddess Magdalenian culture horizontal inheritance Texas A&M University Maui Nadia Abu El-Haj origins of art Navajo Indians gedmatch Jan Ravenspirit Franz

Archive